Nucleosides play a key role in biology processes, involving in the retention, replication and transcription of gene information[1]. Nucleoside analogues can be used as a nucleic acid metabolism inhibitor to interfere with virus reproduction and tumor cell growth, showing good antiviral and anti-tumor effects. Nucleoside drugs are mainly divided into enzyme inhibitors and DNA chain terminators. They are recognized by specific proteins on the cell membrane and then transferred to the cells, which can be monophosphorylated, diphosphorylated and then triphosphorylated by the kinases, including thymidine kinases (TKs), adenosine kinase (AK), deoxycytidine kinase (dCK), and deoxyguanosine kinase (dGK)[2-7].
[1] Journal of Biological Chemistry (2021), 297(1), 100867.
[2] CN112778310 A 2021-05-11.
[3] Journal of Medicinal Chemistry (2021), 64, 7, 4206-4238.
[4] Journal of Medicinal Chemistry (2021), 64, 7, 3911-3939.
[5] Journal of Medicinal Chemistry (2020), 63, 8, 4334-4348.
[6] Journal of Medicinal Chemistry (2019), 62, 19, 8847-8865.
[7] European Journal of Medicinal Chemistry 214 (2021) 113233.
產品編號: 1052622
CAS: 90914-41-3
產品編號: 1125706
CAS: 944902-17-4
產品編號: 1111564
CAS: 1379308-33-4
產品編號: 1121447
CAS: 945950-37-8
產品編號: 1119551
CAS: 1095822-17-5
產品編號: 1125433
CAS: 582313-57-3
產品編號: 1184788
CAS: 1770840-43-1
產品編號: 1023121
CAS: 1651-29-2
產品編號: 1026731
CAS: 23616-57-1
產品編號: 1121951
CAS: 928653-75-2
產品編號: 1064454
CAS: 1000340-34-0
產品編號: 1058441
CAS: 882033-66-1
免費熱線:400-821-0725
官方網址: www.vecc-sepa.org 技術支持郵箱: tech@leyan.com 產品咨詢郵箱: product@leyan.com
現貨供應
專業護航
售后無憂
品質保障
無需湊單